Bodineau Laurence
Professeur des universités
Physiologie respiratoire (1997-en cours) : Caractérisation des mécanismes à l’origine de l’adaptation de la commande respiratoire à l’hypoxie ; Interactions entre les systèmes « progestéronergiques » et la commande respiratoire ; évaluation de leur capacité à exercer une facilitation de la ventilation corrigeant les troubles associés à un dysfonctionnement de la chémosensibilité au CO2 rencontrée dans le cas de syndromes d'hypoventilation centrale ; Influence des systèmes leptinergiques sur l'adaptation de la ventilation à l'hypercapnie ; Influence des hormones sexuelles sur la plasticité neuronale du réseau respiratoire induite par l'hypoxie chronique intermittente ; Mécanismes par lesquels l'EPO influence la commande ventilatoire ; Perturbations de la commande ventilatoire dans la maladie de Steinert ; Neuroplasticité respiratoire induite par stimulation en courant continu appliquée au niveau de la moelle épinière cervicale chez le rongeur ; Impact de la COVID-19 sur la neurophysiologie respiratoire
Physiologie cardiovasculaire (2005-2011) : Organisation et le rôle fonctionnel du système rénine-angiotensine encéphalique dans la physiologie cardiovasculaire
Endocrinologie (2005-2011) : Interaction apéline/ocytocine dans une boucle régulatrice neuro-hormonale maintenant l’homéostasie.
Physiologie de la prise alimentaire (2008-2019) : Mécanismes vagaux associés aux effets du peptide Neuromedin U sur la vidange gastrique ; Implication de l’apéline dans les réseaux contrôlant la prise alimentaire
Physiologie de la douleur (2017-en cours) : Développement d’un modèle ex vivo d’étude de la douleur cornéenne ; Manipulation des systèmes opïoidergiques dans le cadre des douleurs cornéennes ; Impact d'une infection par le SARS-Cov2 sur les voies nociceptives cornéennes
UMR_S1158 Inserm/Sorbonne Université, Neurophysiologie Respiratoire Expérimentale et Clinique, Faculté de Santé - Site Pitié-Salpêtrière
Directrice adjointe de l’UMR_S1158 ; Responsable du laboratoire de recherche sur l’animal au sein de l’UMR_S1158 (Physiologie & Plasticité du Contrôle Respiratoire) ; Co-responsable de l'axe "Hypoventilation centrale acquise et congénitale, neurophysiologie respiratoire du sommeil"--UMR_S1158
Enseignements en Sciences de la Vie et de la Terre à l’INSPE de Paris - Sorbonne Université pour la formation initiale et continue des professeurs des premier et second degrés
Co-Responsable du Département de Sciences de la vie et de la Terre
-Delucenay-Clarke R, Niérat MC, Frugière A, Similowski T, Cayetanot F, Bodineau L (2024). Direct current stimulation as a non-invasive therapeutic alternative for treating autonomic or non-autonomic neurological disorders affecting breathing. Clin Auton Res Aug;34(4):395-411.
-Laveneziana P, Fossé Q, Bret M, Patout M, Dudoignon B, Llontop C, Morélot-Panzini C, Cayetanot F, Bodineau L, Straus C, Similowski T (2024). Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome. Pulmonology Feb 24:S2531-0437(24)00009-6.
-Tsuji M, Mukai T, Sato Y, Azuma Y, Yamamoto S, Cayetanot F, Bodineau L, Onoda A, Nagamura-Inoue T, Coq JO (2023). Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight. Sci Rep Mar 7;13(1):3841.
-Casciato A, Bianchi L, Reverdy M, JoubertF, Delucenay-ClarkeR, Parrot S, Ramanantsoa N, Sizun E, Matrot B, Straus C, Similowski T, Cayetanot F, Bodineau L (2023). Serotonin and the ventilatory effects of etonogestrel, a gonane progestin, in a murine model of congenital central hypoventilation syndrome. Frontiers in Endocrinology. Feb 21;14:1077798. doi: 10.3389/fendo.2023.1077798.
-Taytard J, Niérat MC, Gand C, Lavault S, Morélot-Panzini C, Patout M, Serresse L, Wattiez N, Bodineau L, Straus C, Similowski T (2023). Short-term cognitive loading deteriorates breathing pattern and gas exchange in adult patients with congenital central hypoventilation syndrome. ERJ Open Res. 2023 Mar 13;9(2):00408-2022. doi: 10.1183/23120541.00408-2022. eCollection 2023 Mar.
-Casciato A, Cayetanot F, Bodineau L (2022). Alone or combined with serotoninergic agents, the progestins of the gonane family may represent a therapeutic alternative for Ondine's curse syndrome. Rev Mal Respir. Feb;39(2):95-99.
-Bajjig A, Cayetanot F, Taylor JA, Bodineau L, Vivodtzev I (2022). Serotonin 1A Receptor Pharmacotherapy and Neuroplasticity in Spinal Cord Injury. Pharmaceuticals (Basel) . Apr 11;15(4):460.
-Caravagna C, Casciato A, Coq JO , Liabeuf S, Brocard C, Peyronnet J, Bodineau L, Cayetanot F (2022). Prenatal Hypoxia Induces Cl- Cotransporters KCC2 and NKCC1 Developmental Abnormality and Disturbs the Influence of GABAA and Glycine Receptors on Fictive Breathing in a Newborn Rat. Front Physiol. Feb 16;13:786714
-Jeton F, Perrin-Terrin AS, Yegen CH, Marchant D, Richalet JP, Pichon A, Boncoeur E, Bodineau L, Voituron N (2022). In Transgenic Erythropoietin Deficient Mice, an Increase in Respiratory Response to Hypercapnia Parallels Abnormal Distribution of CO2/H+-Activated Cells in the Medulla Oblongata. Front Physiol . Apr 19;13:850418.
-Bajjig A, Michel-Flutot M, Migevent T, Cayetanot F, Bodineau L, Vinit S, Vivodtzev I (2022). Diaphragmatic Activity and Respiratory Function Following C3 or C6 Unilateral Spinal Cord Contusion in Mice. Biology (Basel) Apr 6;11(4):558.
-Straus, C, Teulier, M, Morel, S, Wattiez, N, Hajage, D, Giboin, C, Charbit, B, Dasque, E, Bodineau, L, Chenuel, B, Straus, N, Attali, V, Similowski, T (2020). Baclofen destabilises breathing during sleep in healthy humans: A randomised, controlled, double-blind crossover trial. Br J Clin Pharmacol. 2020 Sep 28. doi: 10.1111/bcp.14569.
-Joubert F, Guerrero-Moreno A, Fakih D, Reboussin E, Gaveriaux-Ruff C, Acosta MC, Gallar J, Sahel JA, Bodineau L, Baudouin C, Rostène W, Mélik-Parsadaniantz S, Réaux-Le Goazigo A (2020). Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice. Biomed Pharmacother. Dec;132:110794. doi: 10.1016/j.biopha.2020.110794.
-Loiseau, C, Casciato, A, Barka, B, Cayetanot, F, Bodineau, L (2019). Orexin neurons contribute to central modulation of respiratory drive by progestins on ex vivo newborn rodent preparations. Front Physiol. 2019 Sep 27;10:1200. doi: 10.3389/fphys.2019.01200. eCollection 2019.
-Jarry, AC, Merah, N, Cisse, F, Cayetanot, F, Fiamma MN, WillemetzA, Gueddouri, D, Barka, B, Valet, P, Guilmeau, S, Bado, A, Le Beyec, J, Bodineau, L, Le Gall, M. (2019).Neuromedin U is a gut peptide that alters oral glucose tolerance by delaying gastric emptying via direct contraction of the pylorus and vagal-dependent mechanisms. FASEB. Apr;33(4):5377-5388
-Joubert, F, Acosta, MDC, Gallar, J, Fakih, D, Sahel, JA, Baudouin, C, Bodineau, L, Mélik Parsadaniantz, S, Réaux-Le Goazigo, A (2018). Effects of corneal injury on ciliary nerve fibre activity and corneal nociception in mice: A behavioural and electrophysiological study. Eur J Pain. Oct 29.
-Baum, DM, Morales Rodriguez, B, Attali, V, Cauhapé, M, Arnulf, I, Cardot, P, Bodineau, L, Fiamma, MN (2018). New Zealand Obese Mice as a Translational Model of Obesity-related Obstructive Sleep Apnea Syndrome. Am J Respir Crit Care Med. Nov 15;198(10):1336-1339.
-Baum, DM, Saussereau, M, Jeton, F, Planes, C, Voituron, N, Cardot, P, Fiamma, MN, Bodineau, L. (2018). Effect of Gender on Chronic Intermittent Hypoxic Fosb Expression in Cardiorespiratory-Related Brain Structures in Mice. Front Physiol. 2018 Jun 25;9:788.
-Coq, JO, Delcour, M, Ogawa, Y, Peyronnet, J, Castets ,F, Turle-Lorenzo, N, Montel, V, Bodineau, L, Cardot, P, Brocard, C, Liabeuf, S, Bastide, B, Canu, MH, Tsuji, M, Cayetanot, F. (2018). Mild Intrauterine Hypoperfusion Leads to Lumbar and Cortical Hyperexcitability, Spasticity, and Muscle Dysfunctions in Rats: Implications for Prematurity. Front Neurol. 2018 Jun 15;9:423.
-Loiseau, C, Cayetanot, F, Joubert, F, Perrin-Terrin, AS, Cardot, P, Fiamma, MN, Frugiere, A, Straus, C, Bodineau, L (2017). Current prspectives for the use of gonane progesteronergic drugs in the treatment of central hypoventilation syndromes. Cruu/ Neuropharmacol. Jul 19 doi: 10.2174/1570159X15666170719104605
-Laouafa, S, Perrin-Terrin, AS, Jeton, F, Elliot-Portal, E, Tam, R, Bodineau, L, Voituron, N Soliz, J (2017). Pharmacological, but not genetic, alteration of neural Epo modifies the CO2/H+ central chemosensitivity in postnatal mice. Respir Physiol Neurobiol. Aug;242:73-79.
-Joubert, F., Loiseau, C., Perrin-Terrin, A.S., Cayetanot, F., Frugière, A., Voituron, N., Bodineau, L. (2016). Key Brainstem Structures Activated during Hypoxic Exposure in One-day-old Mice Highlight Characteristics for Modeling Breathing Network in Premature Infants. Front Physiol. Dec 9;7:609.
-Perrin-Terrin, A.S., Jeton, F., Pichon, A., Frugière, A., Richalet, J.P., Bodineau, L., Voituron, N. (2016). The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo. J Vis Exp. Apr 25;110.
-Joubert, F., Perrin-Terrin, A.S., Verkaeren, E., Cardot, P., Fiamma, M.N., Frugière, A., Rivals, I., Similowski, T., Straus, C., Bodineau, L. (2016). Desogestrel enhances ventilation in ondine patients: Animal data involving serotoninergic systems. Neuropharmacology. Aug; 107:339-50.
-Loiseau, C., Osinski, D., Joubert, F., Straus, C., Similowski, T., Bodineau L. (2014). The progestin etonogestrel enhances the respiratory response to metabolic acidosis in newborn rats. Evidence for a mechanism involving supramedullary structures. Neurosci Lett. 2014 May 1;567:63-7.
-Hus-Citharel, A., Bodineau, L., Frugière, A., Joubert, F., Bouby, N., Llorens-Cortes, C. (2014). Apelin counteracts vasopressin-induced water reabsorption via cross talk between apelin and vasopressin receptor signaling pathways in the rat collecting duct. Endocrinology. Nov;155(11):4483-93.
-Djenoune, L., Khabou, H., Joubert, F., Quan, FB., Nunes Figueiredo, S., Bodineau, L., Del Bene, F., Burcklé, C., Tostivint, H., Wyart, C. (2014). Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates. Front Neuroanat. 2014 May 6;8:26.
-Leclère, R., Straus, C., Similowski, T., Bodineau, L., Fiamma, M-N. (2012).Persistent lung oscillator response to CO2 after buccal oscillator inhibition in the adult frog. Respir Physiol Neurobiol. Aug 15;183(2) : 166-9.
-Voituron, N., Frugière, A., Mc Kay, L., Romero-Granados, R., Domínguez-del-Toro, E., Saadani-Makki, F., Champagnat, J., Bodineau, L. (2011). The kreisler mutation leads to the loss of intrinsically hypoxia-activated spots in the region of the retrotrapezoid nucleus / parafacial respiratory group. Neuroscience 194 : 95-111.
-Reaux-Le Goazigo, A., Bodineau, L., De Mota, N., Jeandel, L., Chartrel, N., Knauf, C., Raad, C., Valet, P., Llorens-Cortes, C (2011). Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release. Am J Physiol - Endoc and M. 301(5) : E955-66.
-Bodineau, L., Taveau, C., Lê Quan Sang, H.H., Osterstock, G., Queguiner, I., Moos, F., Frugière, A., Llorens-Cortes, C (2011). Data supporting a new physiological role for brain apelin in the regulation of hypothalamic oxytocin neurons in lactating rats. Endocrinology 152(9) : 3492-3503.
-Bodineau, L., Hus-Citharel, A., Llorens-Cortes, C., (2010). Contribution of apelin to water balance, blood glucose control, and cardiovascular functions. Ann Endocrinol (Paris). 71(4):249-56.
-Hus-Citharel, A., Bouby, N., Frugière, A., Bodineau, L., Gasc, JM., Llorens-Cortes, C. (2008). Effect of apelin on glomerular hemodynamic function in the rat kidney. Kidney Int. 74(4) : 486-494.
-Bodineau, L., Frugière, A., Marc, Y., Inguimbert, N., Fassot, C., Balavoine, F., Roques, B., Llorens-Cortes, C. (2008). Orally active aminopeptidase A inhibitors reduce blood pressure. Hypertension 51(5) : 1318-1325.
De Mota, N., Iturrioz, X., Claperon, C., Bodineau, L., Fassot, C., Roques, BP., Palkovits, M., Llorens-Cortes, C. (2008). Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei J. Neurochem. 106(1) : 416-428.
-Bodineau, L., Frugière, A., Marc, Y., Claperon, C., Llorens-Cortes, C. (2008). Aminopeptidase A inhibitors as centrally-acting antihypertensive agents. Heart Fail. Rev. 13(3) : 311-319.
Voituron, N., Frugière, A., Champagnat, J., Bodineau, L. (2006). Hypoxia-sensing properties of the newborn rat ventral meddullary surface in vitro. J. Physiol. 577(Pt1) : 55-68.
-Bodineau, L., Saadani-Makki, F., Jullien, H., Frugière A. (2006). Caffeine in the milk prevents respiratory disorders caused by in utero caffeine exposure in rats. Respir. Physiol. Neurobiol. 150 : 94-98.
-Gaytan, S., Saadani-Makki, F., Bodineau, L., Frugière, A., Larnicol, N., Pasaro, R. (2006). Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem. Auton. Neurosci. 126-127 : 339-346.
-Voituron, N., Frugière, A., Gros, F., Macron, J.M., Bodineau, L. (2005). Diencephalic and mesencephalic influences on the newborn respiratory control in normoxic and hypoxic conditions. An in vitro study on central nervous system preparations isolated from newborn rats. Neuroscience 132 : 843-854.
-Bodineau, L., Cayetanot, F., Marlot, D. Collin, T., Gros, F., Frugière, A. (2004). Endogenous 5-HT1/2 systems and the newborn rat respiratory control. A comparative in vivo and in vitro study. Respir. Physiol. 141 : 47- 57.
-Saadani-Makki, F., Frugière, A., Gaytan, S., Bodineau, L. (2004). Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborn following an in utero caffeine exposure. A study on brainstem-spinal cord preparations isolated from newborn rats. Neuroscience 127 : 505-518.
-Bodineau, L., Cayetanot, F., Saadani-Makki, F., Bach, V., Gros, F., Lebleu, A., Collin, T., Frugière, A. (2003). Consequences of the in utero caffeine exposure on the respiratory output in normoxic and hypoxic conditions and related changes of Fos expression. A study on brainstem-spinal cord preparation isolated from newborn rats. Pediatr. Res. 53 : 266-273.
-Bodineau L. et Larnicol N. (2001). Brainstem and hypothalamic areas activated by tissue hypoxia: Fos-like immunoreactivity induced by carbon monoxide inhalation in the rat. Neuroscience 108 : 643-653.
-Bodineau, L., Cayetanot, F., Frugière, A. (2001). Fos study of pontomedullary areas involved in in vitro hypoxic respiratory depression. Neuroreport 12 : 3913-3916.
-Cayetanot, F., Bodineau, L., Frugière, A. (2001). 5-HT acting on 5-HT1/2 receptors does not participate in the in vitro hypoxic respiratory depression. Neurosci. Res. 41 : 71-78.
-Bodineau, L., Cayetanot, F., Frugière, A. (2000). Possible role of the retrotrapezoid nucleus and parapyramidal area in the respiratory response to anoxia: an in vitro study in neonatal rat. Neurosci. Lett. 295 : 67-69.
-Berquin, P., Bodineau, L., Gros, F., Larnicol, N. (2000). Brainstem and hypothalamic areas involved in respiratory chemoreflexes: a Fos study in adult rats. Brain Res. 857 : 30-40.
-Bodineau, L., Frugière, A., Marlot, D., Wallois, F. (2000). Effect of hypoxia on the activity of respiratory and non respiratory modulated retrotrapezoid neurons of the cat. Auton. Neurosci. 86 : 70-77.
-Bodineau, L., Frugière, A., Marlot, D., Wallois, F. (2000). Connections between retrotrapezoid nucleus and nucleus tractus solitarii in cat. Neurosci. Lett. 280 : 111-114.
-Wallois, F., Bodineau, L., Macron, J.M., Marlot, D., Duron, B. (1997) Role of respiratory and non-respiratory neurones in the region of the NTS in the elaboration of the sneeze reflex in cat. Brain Res. 768 : 71-85.
-Cayetanot F, Frugire A, Morosan S, Bodineau L (2023). Les modèles animaux, des outils indispensables à l’étude de l’infection par le SARS-CoV2. Dossier Covid-19 et cerveau : que savons-nous 3 ans après le début de la pandémie ? Lettre des Neurosciences, printemps/été 2023.
-Charloux, A, Cayetanot, F, Pistea, C, Bodineau, L (2020). Régulation de la ventilation : physiologie et explorations. EMC - Pneumologie 2020:1-18 [Article 6-000-A-73].
-Bodineau, L., Hus-Citharel, A., Llorens-Cortes, C. (2009) Participation de l’apéline au maintien de l’équilibre hydrique et des functions cardiovasculaires. In: Actualités Néphrologiques - Jean Hamburger. Ed. Medecine Sciences, Flammarion pp 127-138.
-Frugière, A. Bodineau, L. (2008) A brief view of the functional organization of the central neuronal network controlling breathing. In: Vegetative functions and their interactions in the neonate. Ed. Chardon, K., Ressign, research signpost pp75-95.
-Iturrioz, X., Réaux-Le Goazigo, A., Hus-Citharel, A., De Mota, N., Bodineau, L., Frugière, A., El Messari, S., Chartrel, N., Kordon, C., Beaudet, A., Vaudry, H., Moos, F., Llorens-Cortes, C. (2006) Central neuropeptide receptors involved in water balance: application to apelin. In: Insights into receptor function and new drug development targets, Research and perspectives in endocrine interactions. Eds. Conn, M., Kordon, C. and Christen, Y. Springer Verlag Berlin Heidelberg pp 79-92.